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How does the COC Protocol work?

The COC Protocol is an individualized therapeutic approach designed to work primarily by restricting the overall ability of cancer cells to take up and use (i.e., ‘metabolize’) energy.

Cancer cells need large amounts of energy to survive, and the majority of cancers use an adaptive process called aerobic glycolysis to generate the excessive energy they need (Kroemer and Pouyssegur, 2008). The COC Protocol may be able to target the various molecular processes involved in and surrounding aerobic glycolysis, and this could help lower the overall metabolic rate of the cancer cell (Jang et al., 2013).

COC Protocol may help to restrict energy supply and use, while simultaneously preventing cancer cells from adapting and using other pathways to take up energy (Jagust et al., 2019). As a result, cancer cells may become weaker and less able to take in and use nutrients they need from their surroundings (e.g., glucose, lipids, and essential amino acids such as glutamine and arginine) (Andrzejewski et al., 2018; Liu et al., 2016). This may make it more difficult overall for cancer cells to survive, grow, and spread in the body. Gradually, the weakened cells (including more resilient and previously treatment-resistant cells) could become more vulnerable to attack from other cellkilling cancer therapies such as radiotherapy, chemotherapy, immunotherapy, hormonal therapy, and targeted therapy (Bradford and Khan, 2013; Chen et al., 2012; Lacerda et al., 2014; Lamb et al., 2015b; Pantziarka et al., 2014).

By targeting the altered metabolic mechanisms which are common to most cancers (but not usually healthy cells), we believe that the COC Protocol has the potential to optimise health for patients with any cancer regardless of specific type, stage, or location.

COC Protocol Mechanisms

Can I take the COC Protocol long-term?

The COC Protocol is primarily designed to be a long- term ‘adjunctive therapy, to help optimize standard treatments. Patients may also take the protocol as a maintenance regime after standard treatment has been completed or during breaks from standard treatment and as part of a long-term strategy to mitigate the risk of recurrence or metastases.

The Care Oncology model

Every patient’s situation is both complex and unique and requires careful personalized assessment. This is why every patient who attends the Care Oncology Clinic is placed under the direct care of clinicians with specialist knowledge of the COC Protocol in the context of cancer. Our clinicians individually assess the potential benefits and risks involved in taking the COC Protocol with each patient.

We will only recommend the COC Protocol to patients when we believe it will be safe and beneficial to do so.

Care is personalised for individual needs, and all our patients receive regular monitoring and support throughout the duration of their treatment with the COC Protocol.

Why do we only prescribe the COC Protocol?

Cancer is a complex disease with complex treatments, and we believe that the potential benefits and risks of adding any further therapies into this mix should be very carefully evaluated

Our knowledge of the existing research, plus our own clinical experience means we are confident that we have a good understanding how the protocol will behave.