Research shows that drugs found in the COC Protocol have an antiproliferative effect on breast cancer tumor cells, meaning that the drug inhibits the growth and spread of cancer cells.

How will the COC Protocol help treat breast cancer?

The COC protocol is a patented pharmaceutical composition of four repositioned medications. The medications have long histories treating type-2 diabetes, reducing cholesterol, parasite infection, bacterial infection and inflammation. After four years of clinical research, we know that these drugs – in combination – offer significant therapeutic value for cancer patients. Each of these drugs plays a role in weakening cancer cells and making them more susceptible to standard-of-care therapy (e.g., chemotherapy, immunotherapy).

One of the biggest problems breast cancer patients face is when their cancer becomes resistant to standard-of-care therapies. Multi-drug resistance (MDR) occurs when a patient develops resistance to one or more treatment drugs.

Care Oncology Featured in;

Care Oncology Featured Media Multi-drug resistance in breast cancer patients is a dangerous phenomenon. When a patient becomes resistant to a cancer drug, the cancer continues growing unchecked until a change in treatment is made — but if your body is resistant to one drug, it has a higher risk of becoming resistant to other drugs.

Breast cancer patients with signs of MDR were included in a published study in the medical journal PLOS One. The study, the result of research led by the College of Medicine at the University of Saskatchewan in Canada, found that a common drug used to treat diabetes is effective in reducing multi-drug resistance once it has occurred.

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A specific class of cholesterol reducing drugs (statins), have shown to reduce the chance of death from breast cancer by up to 38%. Statins do this by reducing the expression of key oncogenes and facilitating a critically important process known as “programmed cell death”, or apoptosis. With the diabetic drug metformin, studies show inhibited growth of multiple types of cancer cells including breast cancer cell lines. Patients under treatment for type 2 diabetes with metformin see increased survivability and reduction in the emergence of new tumors.

COC Cancer Treatment Protocol GlioblastomaSeveral studies have shown that the development of drug resistance (MDR) was delayed or prevented in cells that were pretreated with metformin. Additional experiments conducted in cells cultures and mouse models of aggressive breast cancer uncovered that MDR was reversed after its onset by metformin use.

Independent clinical studies with various cancers show the drugs used in the COC Protocol produce results by enhancing the therapeutic value of standard-of-care and inhibiting molecular processes that produce multi-drug resistance. Studies also show that patients who are administered one or more of these drugs have greater survivability than patients treated with standard-of-care alone.

Is this treatment still effective when a patient is not receiving chemo or other conventional therapies?

Yes, the available evidence supports that being the case i.e. all the medicines have demonstrated beneficial mechanisms of action in cancer which are not dependent on the co-administration of standard therapies.

That said, there is good data on the ability of these medicines to complement standard treatments, for example, rendering cancer cells more sensitive to chemo or radiotherapy. Therefore, your CO physician may recommend running our metabolic treatment in conjunction with conventional therapy where possible.

However, as metabolic treatment is intended to run long-term, many patients take the protocol as a maintenance regime after standard treatment has been completed or during breaks from standard treatment and as part of a long-term strategy to mitigate the risk of recurrence or metastatic spread.

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Breast Cancer and the COC Protocol Drugs


Sensitizes many cancer types including Breast Cancer to chemotherapeutic agents

As a radiotherapy and chemotherapy sensitizer

Discussion of Breast Cancer and metformin with reference to cancer stem cells and metastasis


Support across all forms of Breast Cancer including Triple Negative Breast Cancer TNBC

Statins in Breast Cancer including radio-sensitization

Statin-induced apoptosis in ER+ve BC cell lines


Doxycycline targeting cancer stem cells across many cancer types including Breast Cancer


Mebendazole inhibiting growth in a range of cancer types including Breast Cancer

Mebendazole elicits a potent anti-tumour effect on human cancer cell lines both in vitro and in vivo.

Triple Negative Breast Cancer and the COC Protocol

Triple-negative breast cancer: is there a treatment on the horizon?

Discusses the molecular and clinical characteristics of TNBC and goes on to consider therapeutic options. It looks at PARP and mTOR inhibition (relevant for Metformin), angiogenesis inhibition, the role of tubulin (relevant for Mebendazole) and closes with a section on lipophilic statins in terms of anti-proliferative, pro-apoptotic, anti-invasive, and radio- and chemo-sensitizing properties.

Metformin-Induced Killing of Triple Negative Breast Cancer Cells

Metformin suppresses Triple Negative Breast Cancer Stem Cells

Statin induces inhibition of Triple Negative Breast Cancer (TNBC) cells

Statin support across all forms of Breast Cancer including TNBC

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like Triple Negative Breast Cancer

Targeting matrix metalloproteinases in cancer: Bringing new life to old ideas – a discussion of doxycycline as MMP inhibitor

Doxycycline and other tetracyclines in the treatment of bone metastasis